PDGF-BB/KLF4/VEGF Signaling Axis in Pulmonary Artery Endothelial Cell Angiogenesis

PDGF-BB/KLF4/VEGF Signaling Axis in Pulmonary Artery Endothelial Cell Angiogenesis

Background: Accumulating evidence suggests that platelet-derived growth factor-BB (PDGF-BB) and vascular endothelial growth factor(VEGF) play a role in the progression of pulmonary arterial hypertension (PAH).Since chronic hypoxia is responsible for intimal hyperplasia and disordered angiogenesis of...

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Bibliographic Details
Main Authors: Songhe Liang, Hao Yu, Xinxin Chen, Tingting Shen, Zhongqi Cui, Genle Si, JunTing Zhang, Yue Cheng, Shiwei Jia, Shasha Song, Xiang Zhang, Xiufeng Yu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Platelet-derived growth factor-BB
Transcription factor Krüppel-like factor 4
Vascular endothelial growth factor
Pulmonary artery endothelial cells
Angiogenesis
Online Access:http://www.karger.com/Article/FullText/475652

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