Antiarrhythmic Effects of Melatonin and Omega-3 Are Linked with Protection of Myocardial Cx43 Topology and Suppression of Fibrosis in Catecholamine Stressed Normotensive and Hypertensive Rats

Antiarrhythmic Effects of Melatonin and Omega-3 Are Linked with Protection of Myocardial Cx43 Topology and Suppression of Fibrosis in Catecholamine Stressed Normotensive and Hypertensive Rats

Cardiac β-adrenergic overstimulation results in oxidative stress, hypertrophy, ischemia, lesion, and fibrosis rendering the heart vulnerable to malignant arrhythmias. We aimed to explore the anti-arrhythmic efficacy of the anti-oxidative and anti-inflammatory compounds, melatonin, and omega-3, and t...

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Bibliographic Details
Main Authors: Barbara Szeiffova Bacova, Csilla Viczenczova, Katarina Andelova, Matus Sykora, Kiranj Chaudagar, Miroslav Barancik, Michaela Adamcova, Vladimir Knezl, Tamara Egan Benova, Peter Weismann, Jan Slezak, Narcisa Tribulova
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Antioxidants
Subjects:
rat heart
isoproterenol
connexin-43
extracellular matrix
ventricular fibrillation
melatonin
Online Access:https://www.mdpi.com/2076-3921/9/6/546

Internet

https://www.mdpi.com/2076-3921/9/6/546

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