Placental effects and transfer of sildenafil in healthy and preeclamptic conditionsResearch in context

Placental effects and transfer of sildenafil in healthy and preeclamptic conditionsResearch in context

Background: The phosphodiesterase-5 inhibitor (PDE5) sildenafil has emerged as a promising treatment for preeclampsia (PE). However, a sildenafil trial was recently halted due to lack of effect and increased neonatal morbidity. Methods: Ex vivo dual-sided perfusion of an isolated cotyledon and wire-...

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Bibliographic Details
Main Authors: Emilie Hitzerd, Michelle Broekhuizen, Katrina M. Mirabito Colafella, Marija Glisic, René de Vries, Birgit C.P. Koch, Michiel A. de Raaf, Daphne Merkus, Sam Schoenmakers, Irwin K.M. Reiss, A.H. Jan Danser, Sinno H.P. Simons
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419303822

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http://www.sciencedirect.com/science/article/pii/S2352396419303822

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