Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells.

Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells.

BACKGROUND: The Hippo pathway regulates organ size by inhibiting cell proliferation and promoting cell apoptosis upon its activation. The Yes Associated Protein 1 (YAP1) is a nuclear effector of the Hippo pathway that promotes cell growth as a transcription co-activator. In human cancer, the YAP1 ge...

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Bibliographic Details
Main Authors: Caroline H Diep, Kelly M Zucker, Galen Hostetter, Aprill Watanabe, Chengcheng Hu, Ruben M Munoz, Daniel D Von Hoff, Haiyong Han
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3291657?pdf=render

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http://europepmc.org/articles/PMC3291657?pdf=render

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