Biochanin A Regulates Key Steps of Inflammation Resolution in a Model of Antigen-Induced Arthritis via GPR30/PKA-Dependent Mechanism

Biochanin A Regulates Key Steps of Inflammation Resolution in a Model of Antigen-Induced Arthritis via GPR30/PKA-Dependent Mechanism

Biochanin A (BCA) is a natural organic compound of the class of phytochemicals known as flavonoids and isoflavone subclass predominantly found in red clover (Trifolium pratense). It has anti-inflammatory activity and some pro-resolving actions, such as neutrophil apoptosis. However, the effect of BC...

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Bibliographic Details
Main Authors: Franciel Batista Felix, Juliana Priscila Vago, Débora de Oliveira Fernandes, Débora Gonzaga Martins, Isabella Zaidan Moreira, William Antonio Gonçalves, Walyson Coelho Costa, Jessica Maria Dantas Araújo, Celso Martins Queiroz-Junior, Gabriel Henrique Campolina-Silva, Frederico Marianetti Soriani, Lirlândia Pires Sousa, Renata Grespan, Mauro Martins Teixeira, Vanessa Pinho
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
biochanin A (PubChem CID 5280373)
arthritis
apoptosis
efferocytosis
Resolution of inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.662308/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.662308/full

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