TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner

TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner

Previous studies have revealed that TIPE1 serves as a tumor suppressor gene in several tumor types. However, we demonstrated that TIPE1 can promote cervical cancer proliferation by suppressing p53 activity. Here, we showed that TIPE1 inhibits cervical cancer cell apoptosis both in vivo and in vitro....

Full description

Bibliographic Details
Main Authors: Jie Jiang, Li Gao, Yongting Lan, Yang Wang, Peiqing Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
apoptosis
p53
cervical cancer
chemoresistance
TIPE1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.593615/full
id doaj-ed61b4f2ca9c41b99c6c0a9fce483a47
record_format Article
spelling doaj-ed61b4f2ca9c41b99c6c0a9fce483a472021-01-15T04:24:52ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-01-011010.3389/fonc.2020.593615593615TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent MannerJie Jiang0Li Gao1Yongting Lan2Yang Wang3Peiqing Zhao4Department of Clinical Laboratory, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaDepartment of Stomatology, Zibo Central Hospital, Shandong University, Zibo, ChinaCenter of Translational Medicine, Zibo Central Hospital, Shandong University, Zibo, ChinaDepartment of Clinical Laboratory, Huantai County People’s Hospital, Zibo, ChinaCenter of Translational Medicine, Zibo Central Hospital, Shandong University, Zibo, ChinaPrevious studies have revealed that TIPE1 serves as a tumor suppressor gene in several tumor types. However, we demonstrated that TIPE1 can promote cervical cancer proliferation by suppressing p53 activity. Here, we showed that TIPE1 inhibits cervical cancer cell apoptosis both in vivo and in vitro. Mechanistically, we revealed that TIPE1 facilitates chemoresistance in a wild-type p53-dependent manner. The results indicated that TIPE1 is responsible for the transition from chemosensitivity to chemoresistance, and that it can serve as a promising target in cervical cancer chemotherapy.https://www.frontiersin.org/articles/10.3389/fonc.2020.593615/fullapoptosisp53cervical cancerchemoresistanceTIPE1
collection DOAJ
language English
format Article
sources DOAJ
author Jie Jiang
Li Gao
Yongting Lan
Yang Wang
Peiqing Zhao
spellingShingle Jie Jiang
Li Gao
Yongting Lan
Yang Wang
Peiqing Zhao
TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
Frontiers in Oncology
apoptosis
p53
cervical cancer
chemoresistance
TIPE1
author_facet Jie Jiang
Li Gao
Yongting Lan
Yang Wang
Peiqing Zhao
author_sort Jie Jiang
title TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
title_short TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
title_full TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
title_fullStr TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
title_full_unstemmed TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
title_sort tipe1 promotes cervical cancer cell chemoresistance to cisplatin in a wild-type p53-dependent manner
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2021-01-01
description Previous studies have revealed that TIPE1 serves as a tumor suppressor gene in several tumor types. However, we demonstrated that TIPE1 can promote cervical cancer proliferation by suppressing p53 activity. Here, we showed that TIPE1 inhibits cervical cancer cell apoptosis both in vivo and in vitro. Mechanistically, we revealed that TIPE1 facilitates chemoresistance in a wild-type p53-dependent manner. The results indicated that TIPE1 is responsible for the transition from chemosensitivity to chemoresistance, and that it can serve as a promising target in cervical cancer chemotherapy.
topic apoptosis
p53
cervical cancer
chemoresistance
TIPE1
url https://www.frontiersin.org/articles/10.3389/fonc.2020.593615/full
work_keys_str_mv AT jiejiang tipe1promotescervicalcancercellchemoresistancetocisplatininawildtypep53dependentmanner
AT ligao tipe1promotescervicalcancercellchemoresistancetocisplatininawildtypep53dependentmanner
AT yongtinglan tipe1promotescervicalcancercellchemoresistancetocisplatininawildtypep53dependentmanner
AT yangwang tipe1promotescervicalcancercellchemoresistancetocisplatininawildtypep53dependentmanner
AT peiqingzhao tipe1promotescervicalcancercellchemoresistancetocisplatininawildtypep53dependentmanner
_version_ 1724337674025697280

Similar Items