Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes

Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes

Polycomb repressive complex-1 (PRC1) is essential for the epigenetic regulation of gene expression. SCML2 is a mammalian homolog of Drosophila SCM, a Polycomb-group protein that associates with PRC1. In this study, we show that SCML2A, an SCML2 isoform tightly associated to chromatin, contributes to...

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Bibliographic Details
Main Authors: Roberto Bonasio, Emilio Lecona, Varun Narendra, Philipp Voigt, Fabio Parisi, Yuval Kluger, Danny Reinberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-07-01
Series:eLife
Subjects:
Polycomb
noncoding RNA
chromatin
SCML2
PRC1
MBT
Online Access:https://elifesciences.org/articles/02637

Internet

https://elifesciences.org/articles/02637

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