Decitabine Inhibits Gamma Delta T Cell Cytotoxicity by Promoting KIR2DL2/3 Expression

Decitabine Inhibits Gamma Delta T Cell Cytotoxicity by Promoting KIR2DL2/3 Expression

Gamma delta (γδ) T cells, which possess potent cytotoxicity against a wide range of cancer cells, have become a potential avenue for adoptive immunotherapy. Decitabine (DAC) has been reported to enhance the immunogenicity of tumor cells, thereby reinstating endogenous immune recognition and tumor ly...

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Bibliographic Details
Main Authors: Chao Niu, Min Li, Shan Zhu, Yongchong Chen, Lei Zhou, Dongsheng Xu, Wei Li, Jiuwei Cui, Yongjun Liu, Jingtao Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
DNA methyltransferase inhibitor
adoptive cell immunotherapy
DNA methylation
killer Ig-like receptors
myelodysplastic syndrome
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00617/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00617/full

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