The association of elevated maternal genetic risk scores for hypertension, type 2 diabetes and obesity and having a child with a congenital heart defect.

The association of elevated maternal genetic risk scores for hypertension, type 2 diabetes and obesity and having a child with a congenital heart defect.

<h4>Background</h4>Maternal hypertension, type 2 diabetes (T2D) and obesity are associated with an increased risk of having offspring with conotruncal heart defects (CTDs). Prior studies have identified sets of single nucleotide polymorphisms (SNPs) that are associated with risk for each...

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Bibliographic Details
Main Authors: Michelle Kaplinski, Deanne Taylor, Laura E Mitchell, Dorothy A Hammond, Elizabeth Goldmuntz, A J Agopian, Pediatric Cardiac Genomics Consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0216477

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https://doi.org/10.1371/journal.pone.0216477

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