Integrative eQTL-weighted hierarchical Cox models for SNP-set based time-to-event association studies

Integrative eQTL-weighted hierarchical Cox models for SNP-set based time-to-event association studies

Abstract Background Integrating functional annotations into SNP-set association studies has been proven a powerful analysis strategy. Statistical methods for such integration have been developed for continuous and binary phenotypes; however, the SNP-set integrative approaches for time-to-event or su...

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Bibliographic Details
Main Authors: Haojie Lu, Yongyue Wei, Zhou Jiang, Jinhui Zhang, Ting Wang, Shuiping Huang, Ping Zeng
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Translational Medicine
Subjects:
Integrative analysis
SNP-set association study
Joint effect test
Hierarchical modeling
Cox model
Expression quantitative trait loci
Online Access:https://doi.org/10.1186/s12967-021-03090-z

Internet

https://doi.org/10.1186/s12967-021-03090-z

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