IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts

IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts

Abstract Background Metastatic breast cancer carries a poor prognosis despite the success of newly targeted therapies. Treatment options remain especially limited for the subtype of triple negative breast cancer (TNBC). Several signaling pathways, including NF-κB, are altered in TNBC, and the comple...

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Bibliographic Details
Main Authors: Carrie D. House, Valentina Grajales, Michelle Ozaki, Elizabeth Jordan, Helmae Wubneh, Danielle C. Kimble, Jana M. James, Marianne K. Kim, Christina M. Annunziata
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Cancer
Subjects:
NF-kappaB
Triple negative breast cancer
IKK-epsilon
Non-canonical signaling
Anoikis
Online Access:http://link.springer.com/article/10.1186/s12885-018-4507-2

Internet

http://link.springer.com/article/10.1186/s12885-018-4507-2

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