Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance.

Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance.

Evidence of antibody isotype/subtype switching may provide prognostic value regarding the state of immune responses to therapeutic proteins, e.g. anti-factor VIII (FVIII) antibodies that develop in many hemophilia A patients, clinically termed "inhibitors". A sensitive, high- information-c...

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Bibliographic Details
Main Authors: Kenneth B Lewis, Richard J Hughes, Melinda S Epstein, Neil C Josephson, Christine L Kempton, Craig M Kessler, Nigel S Key, Tom E Howard, Rebecca Kruse-Jarres, Jeanne M Lusher, Christopher E Walsh, Raymond G Watts, Ruth A Ettinger, Kathleen P Pratt, PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3648518?pdf=render

Internet

http://europepmc.org/articles/PMC3648518?pdf=render

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