The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes.

The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes.

The female steroid, 17β-estradiol (E2), is important for pancreatic β-cell function and acts via at least three estrogen receptors (ER), ERα, ERβ, and the G-protein coupled ER (GPER). Using a pancreas-specific ERα knockout mouse generated using the Cre-lox-P system and a Pdx1-Cre transgenic line (PE...

Full description

Bibliographic Details
Main Authors: Gamze Kilic, Ana I Alvarez-Mercado, Bader Zarrouki, Darren Opland, Chong Wee Liew, Laura C Alonso, Martin G Myers, Jean-Christophe Jonas, Vincent Poitout, Rohit N Kulkarni, Franck Mauvais-Jarvis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3912162?pdf=render

Internet

http://europepmc.org/articles/PMC3912162?pdf=render

Similar Items