Deletion of <i>Col15a1</i> Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the <i>MMTV-PyMT</i> Mouse Mammary Carcinoma Model

Deletion of <i>Col15a1</i> Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the <i>MMTV-PyMT</i> Mouse Mammary Carcinoma Model

Basement membrane (BM) zone-associated collagen XV (ColXV) has been shown to suppress the malignancy of tumour cells, and its restin domain can inhibit angiogenesis. In human breast cancer, as well as in many other human carcinomas, ColXV is lost from the epithelial BM zone prior to tumour invasion....

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Bibliographic Details
Main Authors: Guillermo Martínez-Nieto, Ritva Heljasvaara, Anne Heikkinen, Hanne-Kaisa Kaski, Raman Devarajan, Otto Rinne, Charlotta Henriksson, Emmi Thomson, Camilla von Hertzen, Ilkka Miinalainen, Heli Ruotsalainen, Taina Pihlajaniemi, Sanna-Maria Karppinen
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
angiogenesis
breast cancer
collagen XV
ECM remodelling
fibrosarcoma
MMTV-PyMT
Online Access:https://www.mdpi.com/1422-0067/22/18/9978

Internet

https://www.mdpi.com/1422-0067/22/18/9978

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