CHIP, a carboxy terminus HSP-70 interacting protein, prevents cell death induced by endoplasmic reticulum stress in the central nervous system

CHIP, a carboxy terminus HSP-70 interacting protein, prevents cell death induced by endoplasmic reticulum stress in the central nervous system

Endoplasmic reticulum (ER) stress and protein misfolding are associated with various neurodegenerative diseases. ER stress activates Unfolded Protein Response (UPR), an adaptative response. However, severe ER stress can induce cell death. Here we show that the E3 ubiquitin ligase and co-chaperone Ca...

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Bibliographic Details
Main Authors: Felipe eCabral Miranda, Juliana eAdão-Novaes, William eHauswirth, Rafael eLinden, Hilda ePetrs Silva, Luciana Barreto Chiarini
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Hippocampus
neurodegeneration
er stress
ChIP
UPR signaling pathways
AAV-vectors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00438/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00438/full

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