Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

Mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia and primary myelofibrosis patients. To address the contribution of the human CALR mutants to the pathogenesis of myeloproliferative neoplasms (MPNs) in an endogenous context, we modeled the CALRdel52 and CAL...

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Bibliographic Details
Main Authors: Lise Secardin, Cintia Gomez Limia, Suzana da Silva-Benedito, Larissa Lordier, Mira El-Khoury, Caroline Marty, Jean-Christophe Ianotto, Hana Raslova, Stefan N. Constantinescu, Martín Hernán Bonamino, William Vainchenker, Barbara Monte-Mor, Antonio Di Stefano, Isabelle Plo
Format: Article
Language:English
Published: Wolters Kluwer 2021-07-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000593

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http://journals.lww.com/10.1097/HS9.0000000000000593

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