Unsolved mysteries in NLR biology

NOD-like receptors (NLRs) are a class of cytoplasmic pattern recognition receptors. Although most NLRs play some role in immunity, their functions range from regulating antigen presentation (NLRC5, CIITA) to pathogen/damage sensing (NLRP1, NLRP3, NLRC1/2, NLRC4) to suppression or modulation of infla...

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Bibliographic Details
Main Authors: Christopher eLupfer, Thirumala-Devi eKanneganti
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00285/full