Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal function.

Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal function.

Translation elongation factor isoform eEF1A2 is expressed in muscle and neurons. Deletion of eEF1A2 in mice gives rise to the neurodegenerative phenotype "wasted" (wst). Mice homozygous for the wasted mutation die of muscle wasting and neurodegeneration at four weeks post-natal. Although t...

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Bibliographic Details
Main Authors: Lowri A Griffiths, Jennifer Doig, Antonia M D Churchhouse, Faith C J Davies, Charlotte E Squires, Helen J Newbery, Catherine M Abbott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3405021?pdf=render

Internet

http://europepmc.org/articles/PMC3405021?pdf=render

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