Selective inhibition of soluble TNF using XPro1595 relieves pain and attenuates cerulein-induced pathology in mice

Selective inhibition of soluble TNF using XPro1595 relieves pain and attenuates cerulein-induced pathology in mice

Abstract Background Symptoms associated with acute pancreatitis can be debilitating, and treatment remains a challenge. This study aimed to investigate the efficacy of selectively inhibiting the soluble form of TNF (solTNF) using the biologic XPro1595 in a mouse model of acute pancreatitis. Methods...

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Bibliographic Details
Main Authors: Rajasa Randhi, Melissa Damon, Kirsty J. Dixon
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Gastroenterology
Subjects:
Acute pancreatitis
Cerulein
Mice
Inflammation
Cytokines
TNF
Online Access:https://doi.org/10.1186/s12876-021-01827-0

Internet

https://doi.org/10.1186/s12876-021-01827-0

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