Identification of direct target engagement biomarkers for kinase-targeted therapeutics.

Identification of direct target engagement biomarkers for kinase-targeted therapeutics.

Pharmacodynamic (PD) biomarkers are an increasingly valuable tool for decision-making and prioritization of lead compounds during preclinical and clinical studies as they link drug-target inhibition in cells with biological activity. They are of particular importance for novel, first-in-class mechan...

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Bibliographic Details
Main Authors: Cloud P Paweletz, Jannik N Andersen, Roy Pollock, Kumiko Nagashima, Mansuo L Hayashi, Shangshuan U Yu, Hongbo Guo, Ekaterina V Bobkova, Zangwei Xu, Alan Northrup, Peter Blume-Jensen, Ronald C Hendrickson, An Chi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3200335?pdf=render

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http://europepmc.org/articles/PMC3200335?pdf=render

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