Deficiency of STING Promotes Collagen-Specific Antibody Production and B Cell Survival in Collagen-Induced Arthritis

Deficiency of STING Promotes Collagen-Specific Antibody Production and B Cell Survival in Collagen-Induced Arthritis

The levels of interferon-alpha are high in the serum and synovial fluid of rheumatoid arthritis (RA) patients. Activation of the stimulator of type I interferon genes (STING) mediates the productions of type I interferon and promotes chronic inflammation. STING plays a significant role in autoimmune...

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Bibliographic Details
Main Authors: Mookmanee Tansakul, Arthid Thim-uam, Thammakorn Saethang, Jiradej Makjaroen, Benjawan Wongprom, Trairak Pisitkun, Prapaporn Pisitkun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
STING
collagen-induced arthritis
autoantibody
B cell receptor
interferon
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01101/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01101/full

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