Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
G-rich RNAs encoded in mitochondrial DNA are prone to form four-stranded structures called G-quadruplexes (G4s). Here the authors show using in vitro and in vivo approaches that GRSF1 promotes melting of G4 RNA structures in mtRNAs, thus leading to their decay by the hSuv3–PNPase complex.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05007-9 |
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Article |
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doaj-ecae75cc636546cf9e7e85d311c816772021-05-11T10:30:28ZengNature Publishing GroupNature Communications2041-17232018-07-019111510.1038/s41467-018-05007-9Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondriaZbigniew Pietras0Magdalena A. Wojcik1Lukasz S. Borowski2Maciej Szewczyk3Tomasz M. Kulinski4Dominik Cysewski5Piotr P. Stepien6Andrzej Dziembowski7Roman J. Szczesny8Institute of Biochemistry and Biophysics Polish Academy of Sciences, Laboratory of RNA Biology and Functional GenomicsInstitute of Biochemistry and Biophysics Polish Academy of Sciences, Laboratory of RNA Biology and Functional GenomicsInstitute of Biochemistry and Biophysics Polish Academy of Sciences, Laboratory of RNA Biology and Functional GenomicsInstitute of Biochemistry and Biophysics Polish Academy of Sciences, Laboratory of RNA Biology and Functional GenomicsInstitute of Biochemistry and Biophysics Polish Academy of Sciences, Laboratory of RNA Biology and Functional GenomicsInstitute of Biochemistry and Biophysics Polish Academy of Sciences, Laboratory of RNA Biology and Functional GenomicsInstitute of Biochemistry and Biophysics Polish Academy of Sciences, Laboratory of RNA Biology and Functional GenomicsInstitute of Biochemistry and Biophysics Polish Academy of Sciences, Laboratory of RNA Biology and Functional GenomicsInstitute of Biochemistry and Biophysics Polish Academy of Sciences, Laboratory of RNA Biology and Functional GenomicsG-rich RNAs encoded in mitochondrial DNA are prone to form four-stranded structures called G-quadruplexes (G4s). Here the authors show using in vitro and in vivo approaches that GRSF1 promotes melting of G4 RNA structures in mtRNAs, thus leading to their decay by the hSuv3–PNPase complex.https://doi.org/10.1038/s41467-018-05007-9 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Zbigniew Pietras Magdalena A. Wojcik Lukasz S. Borowski Maciej Szewczyk Tomasz M. Kulinski Dominik Cysewski Piotr P. Stepien Andrzej Dziembowski Roman J. Szczesny |
| spellingShingle |
Zbigniew Pietras Magdalena A. Wojcik Lukasz S. Borowski Maciej Szewczyk Tomasz M. Kulinski Dominik Cysewski Piotr P. Stepien Andrzej Dziembowski Roman J. Szczesny Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria Nature Communications |
| author_facet |
Zbigniew Pietras Magdalena A. Wojcik Lukasz S. Borowski Maciej Szewczyk Tomasz M. Kulinski Dominik Cysewski Piotr P. Stepien Andrzej Dziembowski Roman J. Szczesny |
| author_sort |
Zbigniew Pietras |
| title |
Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria |
| title_short |
Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria |
| title_full |
Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria |
| title_fullStr |
Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria |
| title_full_unstemmed |
Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria |
| title_sort |
dedicated surveillance mechanism controls g-quadruplex forming non-coding rnas in human mitochondria |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-07-01 |
| description |
G-rich RNAs encoded in mitochondrial DNA are prone to form four-stranded structures called G-quadruplexes (G4s). Here the authors show using in vitro and in vivo approaches that GRSF1 promotes melting of G4 RNA structures in mtRNAs, thus leading to their decay by the hSuv3–PNPase complex. |
| url |
https://doi.org/10.1038/s41467-018-05007-9 |
| work_keys_str_mv |
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