Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria

Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria

G-rich RNAs encoded in mitochondrial DNA are prone to form four-stranded structures called G-quadruplexes (G4s). Here the authors show using in vitro and in vivo approaches that GRSF1 promotes melting of G4 RNA structures in mtRNAs, thus leading to their decay by the hSuv3–PNPase complex.

Bibliographic Details
Main Authors: Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski, Roman J. Szczesny
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05007-9

Internet

https://doi.org/10.1038/s41467-018-05007-9

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