The regulatory pattern of target gene expression by aberrant enhancer methylation in glioblastoma

The regulatory pattern of target gene expression by aberrant enhancer methylation in glioblastoma

Abstract Background Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor with grim prognosis. Aberrant DNA methylation is an epigenetic mechanism that promotes GBM carcinogenesis, while the function of DNA methylation at enhancer regions in GBM remains poorly...

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Bibliographic Details
Main Authors: Xiaoxiao Zhao, Jianghuai Ji, Shijia Wang, Rendong Wang, Qiuhong Yu, Dongguo Li
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Bioinformatics
Subjects:
Glioblastoma multiforme
Enhancer region
DNA methylation
Epigenetic regulation
Biomarker
Online Access:https://doi.org/10.1186/s12859-021-04345-8

Internet

https://doi.org/10.1186/s12859-021-04345-8

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