Nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway

Nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway

Macrophages and osteoclasts are both derived from monocyte/macrophage lineage, which plays as the osteoclastic part of bone metabolism. Although they are regulated by bone implant surface nanoarchitecture and involved in osseointegration, the beneath mechanism has not been simultaneously analyzed in...

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Bibliographic Details
Main Authors: Yide He, Zhe Li, Xin Ding, Boya Xu, Jinjin Wang, Yi Li, Fanghao Chen, Fanhui Meng, Wen Song, Yumei Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-02-01
Series:Bioactive Materials
Subjects:
Nanoporous implant
Osteogenesis
Osteoclastogenesis
FAK phosphorylation
MAPK
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21003194

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http://www.sciencedirect.com/science/article/pii/S2452199X21003194

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