A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes

A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes

Abstract Background Radiotherapy for head and neck squamous cell carcinomas (HNSCC) is associated with a substantial morbidity and inconsistent efficacy. Human papillomavirus (HPV)-positive status is recognized as a marker of increased radiosensitivity. Our goal was to identify molecular markers ass...

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Bibliographic Details
Main Authors: Jean-Philippe Foy, Louis Bazire, Sandra Ortiz-Cuaran, Sophie Deneuve, Janice Kielbassa, Emilie Thomas, Alain Viari, Alain Puisieux, Patrick Goudot, Chloé Bertolus, Nicolas Foray, Youlia Kirova, Pierre Verrelle, Pierre Saintigny
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Medicine
Subjects:
Head neck squamous cell carcinomas
Molecular subtypes
Predictive biomarker
Radiation therapy
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Resistance
Online Access:http://link.springer.com/article/10.1186/s12916-017-0929-y

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http://link.springer.com/article/10.1186/s12916-017-0929-y

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