M2-AChR Mediates Rapid Antidepressant Effects of Scopolamine Through Activating the mTORC1-BDNF Signaling Pathway in the Medial Prefrontal Cortex

M2-AChR Mediates Rapid Antidepressant Effects of Scopolamine Through Activating the mTORC1-BDNF Signaling Pathway in the Medial Prefrontal Cortex

Background: Scopolamine, a non-selective muscarinic acetylcholine receptor (M1~5-AChR) antagonist, has rapid and robust antidepressant effects in humans and other species. However, which of the five M-AChRs mediates these therapeutic effects has not been fully identified. Several studies implicate M...

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Bibliographic Details
Main Authors: Shuang Liu, Dandan Shi, Zuoli Sun, Yi He, Jian Yang, Gang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Psychiatry
Subjects:
scopolamine
muscarinic acetylcholine receptor-2
medial prefrontal cortex
mammalian target of rapamycin complex 1
brain-derived neurotrophic factor
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.601985/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2021.601985/full

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