Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway

Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway

Introduction: Estrogen (17β-estradiol, E2) is well-known to induce cardioprotective effects against ischemia/reperfusion (I/R) injury. We recently reported that acute application of E2 at the onset of reperfusion in vivo induces cardioprotective effects against I/R injury via activation of its non-s...

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Bibliographic Details
Main Authors: Abdulhafiz Imam Aliagan, Ngonidzashe B. Madungwe, Nathalie Tombo, Yansheng Feng, Jean C. Bopassa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Endocrinology
Subjects:
G protein-coupled estrogen receptor 1 (GPER1)
rat cardiomyoblasts
mitochondrial function
MST1/YAP pathway
mPTP opening
mitochondrial dynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.579161/full

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https://www.frontiersin.org/articles/10.3389/fendo.2020.579161/full

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