Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARγ−/−, PPARδ−/−, PPARγδ−/−, or LXRαβ−/− bone marrow

Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARγ−/−, PPARδ−/−, PPARγδ−/−, or LXRαβ−/− bone marrow

Macrophage lipid metabolism and inflammatory responses are both regulated by the nuclear receptors PPAR and LXR. Emerging links between inflammation and metabolic disease progression suggest that PPAR and LXR signaling may alter macrophage function and thereby impact systemic metabolism. In this stu...

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Bibliographic Details
Main Authors: Chaitra Marathe, Michelle N. Bradley, Cynthia Hong, Lily Chao, Damien Wilpitz, Jon Salazar, Peter Tontonoz
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Journal of Lipid Research
Subjects:
PPAR
LXR
macrophage
inflammation
insulin resistance
immune phenotype
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520414452

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http://www.sciencedirect.com/science/article/pii/S0022227520414452

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