MAVS: A Two-Sided CARD Mediating Antiviral Innate Immune Signaling and Regulating Immune Homeostasis

MAVS: A Two-Sided CARD Mediating Antiviral Innate Immune Signaling and Regulating Immune Homeostasis

Mitochondrial antiviral signaling protein (MAVS) functions as a “switch” in the immune signal transduction against most RNA viruses. Upon viral infection, MAVS forms prion-like aggregates by receiving the cytosolic RNA sensor retinoic acid-inducible gene I-activated signaling and further activates/s...

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Bibliographic Details
Main Authors: Yunqiang Chen, Yuheng Shi, Jing Wu, Nan Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Microbiology
Subjects:
antiviral signal transduction
immune homeostasis
mitochondrial antiviral signaling protein
post-translational modification
viral evasion
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.744348/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.744348/full

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