Assessment of Antibody Stability in a Novel Protein-Free Serum Model

Therapeutic proteins can degrade upon administration as they are subjected to a variety of stresses in human body compartments. In vivo degradation may cause undesirable pharmacokinetic/pharmacodynamic profiles. Pre-clinical in vitro models have gained scientific interest as they enable one to evalu...

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Bibliographic Details
Main Authors: Joachim Schuster, Vinay Kamuju, Roman Mathaes
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/13/6/774