A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress

A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress

Obesity is a major risk factor for the development of metabolic syndrome and type 2 diabetes. How obesity contributes to metabolic syndrome is unclear. Free fatty acid (FFA) activation of a non-receptor tyrosine kinase (SRC)-dependent cJun NH2-terminal kinase (JNK) signaling pathway is implicated in...

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Bibliographic Details
Main Authors: Shashi Kant, Claire L. Standen, Caroline Morel, Dae Young Jung, Jason K. Kim, Wojciech Swat, Richard A. Flavell, Roger J. Davis
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
fatty acid
insulin resistance
JNK
JIP1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311324

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http://www.sciencedirect.com/science/article/pii/S2211124717311324

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