Interferon α Enhances B Cell Activation Associated With FOXM1 Induction: Potential Novel Therapeutic Strategy for Targeting the Plasmablasts of Systemic Lupus Erythematosus

Interferon α Enhances B Cell Activation Associated With FOXM1 Induction: Potential Novel Therapeutic Strategy for Targeting the Plasmablasts of Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease. It is characterized by the production of various pathogenic autoantibodies and is suggested to be triggered by increased type I interferon (IFN) signature. Previous studies have identified increased plasmablasts in the peripheral blood of...

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Bibliographic Details
Main Authors: Kanae Akita, Ken Yasaka, Tsuyoshi Shirai, Tomonori Ishii, Hideo Harigae, Hiroshi Fujii
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
B cell
interferon α
plasmablast
FOXM1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.498703/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.498703/full

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