NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation

NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation

Summary: The colon epithelium is a primary point of interaction with the microbiome and is regenerated by a few rapidly cycling colonic stem cells (CSCs). CSC self-renewal and proliferation are regulated by growth factors and the presence of bacteria. However, the molecular link connecting the diver...

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Bibliographic Details
Main Authors: Sjoerd van der Post, George M.H. Birchenough, Jason M. Held
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
colon
stem cells
redox signaling
NADPH oxidases
NOX1
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002631

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http://www.sciencedirect.com/science/article/pii/S2211124721002631

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