Regulation of p14<sup>ARF </sup>expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development

<p>Abstract</p> <p>Background</p> <p>Most human cancers show inactivation of both pRB- and p53-pathways. While retinoblastomas are initiated by loss of the <it>RB1 </it>tumor suppressor gene, <it>TP53 </it>mutations have not been found. High expr...

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Bibliographic Details
Main Authors: To Kwong-Him, Pajovic Sanja, Gallie Brenda L, Thériault Brigitte L
Format: Article
Language:English
Published: BMC 2012-02-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/12/69