Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating

Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating

In contrast to most voltage-gated ion channels, hyperpolarization- and cAMP gated (HCN) ion channels open on hyperpolarization. Structure-function studies show that the voltage-sensor of HCN channels are unique but the mechanisms that determine gating polarity remain poorly understood. All-atom mole...

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Bibliographic Details
Main Authors: Marina A Kasimova, Debanjan Tewari, John B Cowgill, Willy Carrasquel Ursuleaz, Jenna L Lin, Lucie Delemotte, Baron Chanda
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
ion channels
inward rectification
outward rectification
Online Access:https://elifesciences.org/articles/53400

Internet

https://elifesciences.org/articles/53400

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