TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence

TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence

ABSTRACT Human telomerase reverse transcriptase (hTERT) plays a central role in telomere lengthening for continuous cell proliferation, but it remains unclear how extracellular cues regulate telomerase lengthening of telomeres. Here we report that the cytokine bone morphogenetic protein-7 (BMP7) ind...

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Bibliographic Details
Main Authors: Lucy Cassar, Craig Nicholls, Alex R. Pinto, Ruping Chen, Lihui Wang, He Li, Jun-Ping Liu
Format: Article
Language:English
Published: SpringerOpen 2016-09-01
Series:Protein & Cell
Subjects:
BMPRII
TGFbeta
hTERT
telomerase
telomeres
senescence
Online Access:http://link.springer.com/article/10.1007/s13238-016-0322-1

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http://link.springer.com/article/10.1007/s13238-016-0322-1

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