Polysomy and amplification of chromosome 7 defined for EGFR gene in squamous cell carcinoma of the lung together with exons 19 and 21 wild type Carcinoma epidermóide do pulmão: Polissomia e amplificação do cromossoma 7 e do gene EGRF com forma wild type nos exões 19 e 21

Polysomy and amplification of chromosome 7 defined for EGFR gene in squamous cell carcinoma of the lung together with exons 19 and 21 wild type Carcinoma epidermóide do pulmão: Polissomia e amplificação do cromossoma 7 e do gene EGRF com forma wild type nos exões 19 e 21

Purpose: The epidermal growth factor receptor (EGFR) is overexpressed in the majority of nonsmall-cell lung cancers (NSCLC) and is a major target specific EGFR tyrosine kinase inhibitors (TKIs) developed and used for the treatment of advanced NSCLC. A number of biological factors are also associated...

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Bibliographic Details
Main Authors: Patrícia Couceiro, Vítor Sousa, Ana Alarcão, Maria Silva, Lina Carvalho
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Revista Portuguesa de Pneumologia
Subjects:
Carcinoma do pulmão
carcinoma epidermóide
tecido incluído em parafina
EGFR
amplificação
polissomia
Lung cancer
epidermoid carcinoma
paraffin-embedded tissue
gene amplification
gene polysomy
Online Access:http://www.scielo.oces.mctes.pt/scielo.php?script=sci_arttext&pid=S0873-21592010000300007

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