Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction (PPI) has become an important drug target to upregulate the expression of ARE-controlled cytoprotective oxidative stress response enzymes...

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Bibliographic Details
Main Authors: Dhulfiqar Ali Abed, Melanie Goldstein, Haifa Albanyan, Huijuan Jin, Longqin Hu
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Oxidative stress
Keap1
Nrf2
Direct inhibitors of protein–protein interaction
High throughput screening assays
Structure–activity relationships
X-ray crystallography
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383515000829

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http://www.sciencedirect.com/science/article/pii/S2211383515000829

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