High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease

High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease

Abstract Background Differentiating infiltrating myeloid cells from resident microglia in neuroinflammatory disease is challenging, because bone marrow-derived inflammatory monocytes infiltrating the inflamed brain adopt a ‘microglia-like’ phenotype. This precludes the accurate identification of eit...

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Bibliographic Details
Main Authors: Alanna G. Spiteri, Rachel L. Terry, Claire L. Wishart, Thomas M. Ashhurst, Iain L. Campbell, Markus J. Hofer, Nicholas J. C. King
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Neuroinflammation
Viral encephalitis
High-dimensional cytometry
Flavivirus
Immune-mediated pathology
Online Access:https://doi.org/10.1186/s12974-021-02214-y

Internet

https://doi.org/10.1186/s12974-021-02214-y

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