Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis.

Staphylococcus aureus is the most frequent causative organism of osteomyelitis. It is characterised by widespread bone loss and bone destruction. Previously we demonstrated that S. aureus protein A (SpA) is capable of binding to tumour necrosis factor receptor-1 expressed on pre-osteoblastic cells,...

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Bibliographic Details
Main Authors: Amro Widaa, Tania Claro, Timothy J Foster, Fergal J O'Brien, Steven W Kerrigan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3394727?pdf=render