Near infra-red photoimmunotherapy with anti-CEA-IR700 results in extensive tumor lysis and a significant decrease in tumor burden in orthotopic mouse models of pancreatic cancer.

Near infra-red photoimmunotherapy with anti-CEA-IR700 results in extensive tumor lysis and a significant decrease in tumor burden in orthotopic mouse models of pancreatic cancer.

Photoimmunotherapy (PIT) of cancer utilizes tumor-specific monoclonal antibodies conjugated to a photosensitizer phthalocyanine dye IR700 which becomes cytotoxic upon irradiation with near infrared light. In this study, we aimed to evaluate the efficacy of PIT on human pancreatic cancer cells in vit...

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Bibliographic Details
Main Authors: Ali A Maawy, Yukihiko Hiroshima, Yong Zhang, Roger Heim, Lew Makings, Miguel Garcia-Guzman, George A Luiken, Hisataka Kobayashi, Robert M Hoffman, Michael Bouvet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370703?pdf=render

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http://europepmc.org/articles/PMC4370703?pdf=render

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