Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways?

Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways?

Objectives: Diabetic patients respond poorly to revascularization for peripheral arterial disease (PAD) but the underlying mechanisms are not well understood. We aimed to determine whether diabetes worsens ischemia-reperfusion (IR)-induced muscle dysfunction and the involvement of endogenous protect...

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Bibliographic Details
Main Authors: Julien Pottecher, Chris Adamopoulos, Anne Lejay, Jamal Bouitbir, Anne-Laure Charles, Alain Meyer, Mervyn Singer, Valerie Wolff, Pierre Diemunsch, Gilles Laverny, Daniel Metzger, Bernard Geny
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Physiology
Subjects:
diabetes
ischemia-reperfusion
peripheral arterial disease
protective kinases
muscles
mitochondria
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00579/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.00579/full

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