Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity

Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity

Summary: Sex differences in multiple sclerosis (MS) incidence and severity have long been recognized. However, the underlying cellular and molecular mechanisms for why male sex is associated with more aggressive disease remain poorly defined. Using a T cell adoptive transfer model of chronic experim...

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Bibliographic Details
Main Authors: Prenitha Mercy Ignatius Arokia Doss, Muhammad Umair, Joanie Baillargeon, Reda Fazazi, Neva Fudge, Irshad Akbar, Asmita Pradeep Yeola, John B. Williams, Mickael Leclercq, Charles Joly-Beauparlant, Philippe Beauchemin, Gian Filipo Ruda, Melanie Alpaugh, Ana C. Anderson, Paul E. Brennan, Arnaud Droit, Hans Lassmann, Craig S. Moore, Manu Rangachari
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
multiple sclerosis
progressive multiple sclerosis
experimental autoimmune encephalomyelitis
non-obese diabetic
Th17
IFNγ
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721001479

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http://www.sciencedirect.com/science/article/pii/S2211124721001479

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