Thioredoxin-mimetic peptide CB3 lowers MAPKinase activity in the Zucker rat brain

Thioredoxin-mimetic peptide CB3 lowers MAPKinase activity in the Zucker rat brain

Diabetes is a high risk factor for dementia. High glucose may be a risk factor for dementia even among persons without diabetes, and in transgenic animals it has been shown to cause a potentiation of indices that are pre-symptomatic of Alzheimer′s disease. To further elucidate the underlying mechan...

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Bibliographic Details
Main Authors: Moshe Cohen-Kutner, Lena Khomsky, Michael Trus, Hila Ben-Yehuda, James M. Lenhard, Yin Liang, Tonya Martin, Daphne Atlas
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Diabetes type 2
Inflammation
Thioredoxin mimetics
ZDF rat-model
MAPK
AMPK
TXNIP/TBP-2
CB3
Oxidative stress
Redox
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231713001067

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http://www.sciencedirect.com/science/article/pii/S2213231713001067

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