Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors

Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors

Secondary metabolites from natural products are a potential source of acetylcholinesterase inhibitors (AChEIs), which is a key enzyme in the treatment of many neurodegenerative diseases. Inspired by the reported activities of isoquinoline-derivative alkaloids herein we report the design, one step sy...

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Bibliographic Details
Main Authors: Bruna R. de Lima, Juliana M. Lima, Jéssica B. Maciel, Carolina Q. Valentim, Rita de Cássia S. Nunomura, Emerson S. Lima, Hector H. F. Koolen, Afonso Duarte L de Souza, Maria Lúcia B. Pinheiro, Quezia B. Cass, Felipe Moura A. da Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Chemistry
Subjects:
bioaffinity chromatography
molecular docking
on-flow assay
Onychopetalum amazonicum
stepholidine derivatives
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00629/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00629/full

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