BBSome ablation in SF1 neurons causes obesity without comorbidities

BBSome ablation in SF1 neurons causes obesity without comorbidities

Objectives: The hypothalamic ventromedial nucleus (VMH) plays a major role in metabolic control, but the molecular mechanisms involved remain poorly defined. We analyzed the relevance of the BBSome, a protein complex composed of 8 Bardet–Biedl syndrome (BBS) proteins including BBS1, in VMH steroidog...

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Bibliographic Details
Main Authors: Mohamed Rouabhi, Deng-Fu Guo, Donald A. Morgan, Zhiyong Zhu, Miguel López, Leonid Zingman, Justin L. Grobe, Kamal Rahmouni
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Metabolism
Subjects:
Bardet–biedl syndrome proteins
Hypothalamus
Obesity
Hypertension
Insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782100051X

Internet

http://www.sciencedirect.com/science/article/pii/S221287782100051X

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