Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms

Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms

Transcriptional activation of MYC is a hallmark of many B cell lineage neoplasms. MYC provides a constitutive proliferative signal but can also initiate ARF-dependent activation of p53 and apoptosis. The E3 ubiquitin ligase, ARF-BP1, encoded by <em>HUWE1</em>, modulates t...

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Bibliographic Details
Main Authors: Herbert C. Morse III, Jiafang Sun, Delin Chen, William C. Cho, Wei Gu, Shao Xiang, Ziedulla Abdullaev, Ted A. Torrey, Siegfried Janz, Alexander L. Kovalchuk, Yong-Soo Kim, Chen-Feng Qi
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:International Journal of Molecular Sciences
Subjects:
ARF-BP1
B-cell lymphoma
p53
MYC
CTCF
ARF
Online Access:http://www.mdpi.com/1422-0067/13/5/6204

Internet

http://www.mdpi.com/1422-0067/13/5/6204

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