Reporter-Based Screens for the Ubiquitin/Proteasome System

Instant and adequate handling of misfolded or otherwise aberrant proteins is of paramount importance for maintaining protein homeostasis in cells. The ubiquitin/proteasome system (UPS) is a central player in protein quality control as it operates in a seek-and-destroy mode, thereby facilitating elim...

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Bibliographic Details
Main Authors: Maria E. Gierisch, Tatiana A. Giovannucci, Nico P. Dantuma
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00064/full