Pyramidal Cell Loss in Motor Cortices in Huntington's Disease

Patterns of huntingtin protein aggregation and cortical neuronal loss suggest early involvement of corticostriatal pathways in Huntington's disease. However, theories of pathogenesis of chorea rely on the motor cortices being intact. The motor cortices have not previously been studied at a cell...

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Bibliographic Details
Main Authors: Virginia Macdonald, Glenda Halliday
Format: Article
Language:English
Published: Elsevier 2002-08-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905280